Zervikale Intraepitheliale Neoplasie (CIN): Grade, Detektion und Behandlung

CIN (Cervical Intraepithelial Neoplasia) refers to abnormal cell changes in the cervical epithelium (lining of the cervix). It is a precancerous condition—not cancer itself—but can progress to cervical cancer if untreated.

Grading

• CIN 1 (Low-grade): Mild dysplasia; often regresses spontaneously.
• CIN 2 (Moderate): Moderate dysplasia; higher progression risk.
• CIN 3 (High-grade): Severe dysplasia / carcinoma in situ; high progression risk.

Detection & Treatment

• Screening: Pap smear (cervical cytology) ± HPV testing.
• Diagnosis: Colposcopy with biopsy.
• Treatment: Excisional (LEEP, cone biopsy) or ablative (cryotherapy, laser) methods. Choice depends on grade, patient age, fertility desires, and margins.

Regular screening and HPV vaccination are the most effective prevention strategies.