Glutenfreie, kaseinfreie (GFCF) Diät bei Autismus: Evidenz-Review

The GFCF diet eliminates gluten (wheat, rye, barley) and casein (dairy). Some families report improvements; scientific evidence is mixed.

Proposed Mechanism

Opioid-excess theory: incomplete digestion creates peptides (gliadorphin, casomorphin) that cross a “leaky gut” and affect brain function. Not conclusively proven.

Research Summary

• Positive: Some small, open-label studies show behavioral/communication improvements.
• Negative: Larger, controlled trials (e.g., JAMA 2015) found no significant benefit over placebo.
• Systematic reviews: Insufficient evidence for routine recommendation (Cochrane, NICE).

Considerations

• Nutritional risk: requires dietitian supervision to avoid deficiencies (calcium, vitamin D, fiber).
• Cost, social restriction, family burden.
• May benefit subset with GI symptoms or confirmed sensitivities.

Consult your child's doctor and a registered dietitian before starting. Evidence-based behavioral/educational interventions remain first-line.